Carbamazepine is an anticonvusant used to prevent epileptic seizures, and it has also used been widely used to treat tinnitus.
Trials in animals with induced tinnitus, have shown that carbamazepine significantly suppresses the behavioral manifestations of tinnitus. However, there have been few clinical trials supporting its efficacy in humans. As a result we are still unsure on the dosing for carbamazepine treatment, and on its long-term benefits for tinnitus alleviation.
Two Chinese studies in 2008 found that oral administration of carbamazepine had no beneficial effect on tinnitus when compared to a control group who did not receive the drug [[i]][[ii]].
Carbamazepine does carry serious side effects, and without clinical studies to support its efficacy, Its continued use for tinnitus is questionable.
[i] Zheng Y et al. Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats. Acta Otolaryngol. 2008 Jan;128(1):48-52
[ii] Kong X et al. Efficacy of carbamazepine combined with flunarizine hydrochloride for treating tinnitus. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008 Nov;22(22):1016-8, 1022


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